Sign in to follow this  
Followers 0
EricP

acetylcholine trial and error

8 posts in this topic

After a little experimenting with supplements I have discovered a few things about brain fog. Reading many sites will encourage supplements or a diet containing a high choline to help boost acetylcholine which increases memory, focus and cognitive function. So I tried it... And for me it made it 5 times WORSE. So then I read about having too much acetylcholine and the effects are listed about the same as I experienced using these supplements.

So it turns out if dopamine is at a low then acetylcholine tends to be high actually causing a negative effect. Since there is no easy way to boost dopamine without adderall or other prescription methods I decided to stop the choline supplements or any supplement that aids choline; as well as some caution in my diet. While still having the same tiredness and lack of motivation I have noticed a pretty obvious fog lift in mental function. 

I will continue to experiment and report back however this far this has proven to be pretty useful for me. Also supposedly taking benadryl will also block acetylcholine however in past experience it has a drowsy effect so not sure I will try that just yet. 

Just though I would share...

2 people like this

Share this post


Link to post
Share on other sites

Bendryl knocks me out. Do your research find out the trick we need you’ll be a hero! I’ve pretty much given up thinking supplements and diet will ever be the answer. Every time I find something I think is working the placebo effect wears off and back to the drawling board.  Guess really only time alone heals it’s like a 2-4 yr mental prison sentence we all must pay for the years of abuse we did to ourselves. 

5 people like this

Share this post


Link to post
Share on other sites

Paying the piper , prison is a good way to put it 

1 person likes this

Share this post


Link to post
Share on other sites

 If I blacked out behind the wheel from binging on addy for days could have killed someone and actually been in prison. I’d rather take this penalty and should consider myself lucky. Yes it fucking sucks at times but could always be worse.

4 people like this

Share this post


Link to post
Share on other sites
9 hours ago, Frank B said:

 If I blacked out behind the wheel from binging on addy for days could have killed someone and actually been in prison. I’d rather take this penalty and should consider myself lucky. Yes it fucking sucks at times but could always be worse.

i'm horrified at myself sometimes, thinking back how reckless a driver i was on adderall- i was on my phone 90% of the time while driving, and not just "texting". doing shit like rearranging playlists, downloading stuff.. it's a miracle i never killed someone or myself. i did get pulled over once for swerving, dead of the night on a turnpike. i must have been tweaked out of my mind (as usual), but the officer simply accepted my "just tired" explanation. maybe if that had gone another way, i might have been off this shit far sooner.

3 people like this

Share this post


Link to post
Share on other sites

@EricP  my only experience with acetylcholine was while experimenting with nootropics and piracetam. my understanding is that taking a racetam without a ACh supplement can cause headaches and other issues, possibly because the racetam requires more of it to work effectively? not sure how ACh supplements would work outside of this context.

Share this post


Link to post
Share on other sites

@Frank BYeah you are right about the search for supplements. I have gotten a bit sucked in at times. I agree that some things appear to work then fade. I often wonder if it’s more of our minds believing in it sometimes and then the inevitable bad day or crash occurs stripping away the prior hopes. I would love to find a baseline of good vitamins and just stick to a plan however I get frustrated and keep seeking. 

@sleepystupidI read about pricetram as well a bit among others. Haven’t gone down that route as there are just too many nootropics to choose from and if you read the descriptions of each they all sound a bit “amazing” yet at what other side effects? Too much ACh causes headaches as well. 

Overall in my discovery leading to this post I basically over did it with vitamins to improve cognitive performance and was getting way too much ACh causing worsened headaches. I already get some headaches that have been remedied by vitamin B2 however adding the increased ACh came really bad Fog and headaches that couldn’t be remedied easily. 

Share this post


Link to post
Share on other sites

Try uridine tau along with choline. Uridine is known to help rebuild dopamine receptors. Mix b vitamin complex, DHA fish oil and some d3. 

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
Sign in to follow this  
Followers 0